Logic Pro 8 MIDI dropout with LP8

DSP Hungry

Ok.. So I have had this "bug" migrate into my Logic system a few months ago and had time today to trouble shoot.

My AKAI S-5000 that is patched into MIDI port 1 on my Unitor 8 plays as expected when the sequencer is NOT running.

When the sequencer plays I can hardly get a note to sound from the AKAI?
It seems to be dropping out our going out different ports

I've recreated this with my startup template or a fresh new session. Is their a way to trash MIDI prefrences?